Members

Group Leader:

Marc Marti-Renom (ICREA Research Professor)

Staff Scientist:

Davide Baù

Postdoctoral Fellows:

Irene Farabella, Marco di Stefano, Yannick Spill, François Serra

PhD Students:

Silvia Galan, Paula Soler, Francisco Martínez-Jiménez, Gireesh K. Bogu, David Dufour, Carlos Baeza

Technicians:

Yasmina Cuartero, Michael Goodstadt

Selected Publications

Bogu GK, Vizan P, Stanton LW, Beato M, Di Croce L, Marti-Renom MA.
“Chromatin and RNA maps reveal regulatory long noncoding RNAs in mouse.”
Mol Cell Biol, 36(5):809-819 (2015).

Trussart M, Serra F, Baù D, Junier I, Serrano L, Marti-Renom MA.
“Assessing the limits of restraint-based 3D modeling of genomes and genomic domains.”
Nucleic Acids Research, 43(7):3465-3477 (2015).

Belton JM, Lajoie BR, Audibert S, Cantaloube S, Lassadi I, Goiffon I, Baù D, Marti-Renom MA, Bystricky K, Dekker J.
“The conformation of yeast chromosome III is mating type-dependent and controlled by the recombination enhancer.”
Cell Reports, 13:1–13 (2015)

Serra F, Di Stefano M, Spill YG, Cuartero Y, Goodstadt M, Baù D, Marti-Renom MA.
“Restraint-based three-dimensional modeling of genomes and genomic domains.”
FEBS Letters, 589(20):2987–2995 (2015).

Martínez-Jiménez F, Marti-Renom MA.
“Ligand-target prediction by structural network biology using nAnnoLyze.”
PLOS Computational Biology, 11(3):e1004157 (2015).

Summary

We are interested in the molecular mechanisms that regulate cell fate. To study such mechanisms, we employ the laws of physics and the rules of evolution to develop and apply computational methods for predicting the 3D structures of macromolecules and their complexes.

Research projects

Structure determination of genomes. We develop methods for determining the 3D organization of the chromatin.
Comparative RNA structure prediction. We develop a series of tools for the alignment of RNA structures and the prediction of their structures and functions.
Protein-Ligand interactions. We develop methods for comparative docking of small chemical compounds and their target proteins.

Selected Publications

Bogu GK, Vizan P, Stanton LW, Beato M, Di Croce L, Marti-Renom MA.
“Chromatin and RNA maps reveal regulatory long noncoding RNAs in mouse.”
Mol Cell Biol, 36(5):809-819 (2015).

Martínez-Jiménez F, Marti-Renom MA.
“Ligand-target prediction by structural network biology using nAnnoLyze.”
PLOS Computational Biology, 11(3):e1004157 (2015).

Structural Genomics (Group with Dual Affiliation CRG-CNAG)

Gene Regulation, Stem Cells and Cancer

Summary

Research projects