Members

Group Leader:

Fyodor Kondrashov (ICREA Research Professor)

Postdoctoral Fellows:

Peter Vlasov, Romain Derelle, Maria Plyushcheva, Dmitry Ivankov, Natalia Bogatyreva, Ekaterina Putintseva

Students:

Inna Povolotskaya, Margarita Meer, Onuralp Soylemez, Carla Bello, Helena Garka

Technicians:

Victoria Pokusaeva, Oriol Pich, Julia Canet, Dinara Usmanova, Karen Sarkisyan

Selected Publications

Usmanova DR, Ferretti L, Povolotskaya IS, Vlasov PK, Kondrashov FA.
“A model of substitution trajectories in sequence space and long-term protein evolution.”
Mol Biol Evol, 32(2):542-54 (2015).

Kondrashov DA, Kondrashov FA.
“Topological features of rugged fitness landscapes in sequence space.”
Trends Genet, 31(1):24-33 (2015).

Arkhipova OV, Meer MV, Mikoulinskaia GV, Zakharova MV, Galushko AS, Akimenko VK, Kondrashov FA.
“Recent Origin of the Methacrylate Redox System in Geobacter sulfurreducens AM-1 through Horizontal Gene Transfer.”
PLoS One, 10(5):e0125888 (2015).

Kretz CA, Dai M, Soylemez O, Yee A, Desch KC, Siemieniak D, Tomberg K, Kondrashov FA, Meng F, Ginsburg D.
“Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13.”
Proc Natl Acad Sci U S A, 112(30):9328-33 (2015).

Summary

Our group is interested in all aspects of genome evolution, structure and function. We typically use computational and theoretical methods to address various evolutionary issues. In the last year we have made steps to expand our experimental capabilities, in part thanks to several collaborations.

Research projects

In the last year we have:

Created the first model of protein evolution that takes into account propensity of epistatic interactions (publication 1)

Presented a review on the complex nature of fitness landscapes (publication 2)

Found that the methacrylate redox system of Geobacter sulfurreducens AM-1 was acquired through a recent horizontal transfer event (publication 3)

Studied the mutational landscape of the metalloprotease enzyme ADAMTS13 (publication 4)

Selected Publications

Usmanova DR, Ferretti L, Povolotskaya IS, Vlasov PK, Kondrashov FA.
“A model of substitution trajectories in sequence space and long-term protein evolution.”
Mol Biol Evol, 32(2):542-54 (2015).

Kondrashov DA, Kondrashov FA.
“Topological features of rugged fitness landscapes in sequence space.”
Trends Genet, 31(1):24-33 (2015).

Evolutionary Genomics

Bioinformatics and Genomics

Summary

Research projects