Members

This group is part of the EMBL/CRG Research Unit in Systems Biology.

Group Leader:

Luis Serrano (ICREA Research Professor)

Staff Scientists:

Christina Kiel, Maria Lluch

Postdoctoral Fellows:

Eva Yus, Javier Delgado, Besray Unal (Interpod program with Yogi Jaeger), Jae-Seong Yang, Martin Schaeffer, Claire Lastrucci

Students:

Marie Jeanne Trussart, Veronica Llorens, Carolina Gallo, Daniel Shaw

Technicians:

Sira Martinez, Tony Ferrar, Violeta Beltran, Hannah Benisty

Visiting Scientist:

Lenore Cowan

Selected Publications

Llorens-Rico V, Lluch-Senar M, et al.
“Distinguishing between productive and abortive promoters using a random forest classifier in Mycoplasma pneumoniae.”
Nucleic Acids Res, 43(7):3442-53 (2015).

Lluch-Senar M, Delgado J, et al.
“Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.”
Mol Syst Biol, 11:780 (2015).

O’Leary L, van der Sloot AM, et al.
“Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity.”
Oncogene,Epub 2015 Jun 8.

Trussart M, Serra F, et al.
“Assessing the limits of restraint-based 3D modeling of genomes and genomic domains.”
Nucleic Acids Res, 43(7):3465-77 (2015).

Toufighi K, Yang JS, et al.
“Dissecting the calcium-induced differentiation of human primary keratinocytes stem cells by integrative and structural network analyses.”
PLoS Comput Biol, 11(5):e1004256 (2015).

Verschueren E, Spiess M, et al. (2015).
“Evolution of the SH3 Domain Specificity Landscape in Yeasts.”
PLoS ONE, 10(6): e0129229 (2015).

Summary

Our group is interested in the quantitative understanding and rational engineering of living systems (ranging from gene networks to organisms). For this purpose, we use a combination of tools that involve software for protein design and simulations of networks and experimental approaches. Our approach is based on first understanding a system and then engineering it to obtain the properties we want. Our philosophy is also whenever possible identifying the possible practical applications for human health and biotechnology of our work.

Figure 1. Essentiality landscape of M. pneumoniae (Mol Syst Biol, 11:780.) — Figure 1

Research projects

Quantitative understanding and whole-cell modelling of a whole organism: M. pneumoniae
Engineering of M. pneumoniae to treat human diseases.
Quantitative understanding of Signal Transduction in humans and its role in disease

Selected Publications

Lluch-Senar M, Delgado J, et al.
“Defining a minimal cell: essentiality of small ORFs and ncRNAs in a genome-reduced bacterium.”
Mol Syst Biol, 11:780 (2015).

Trussart M, Serra F, et al.
“Assessing the limits of restraint-based 3D modeling of genomes and genomic domains.”
Nucleic Acids Res, 43(7):3465-77 (2015).

Verschueren E, Spiess M, et al. (2015).
“Evolution of the SH3 Domain Specificity Landscape in Yeasts.”
PLoS ONE, 10(6): e0129229 (2015).